• Cytochrome P450

    These are drug-metabolizing enzymes, commonly known as CYP which are found in the liver and are responsible for the metabolism of a large number of pharmaceutical compounds.

    Expression of each CYP is influenced by a unique combination of mechanisms and factors including genetic polymorphisms, induction by xenobiotics, regulation by cytokines, hormones and during disease states, as well as sex, age, and others. Multiallelic genetic polymorphisms, which strongly depend on ethnicity, play a major role for the function of CYPs and leading to distinct pharmacogenomic phenotypes termed as poor, intermediate, extensive, and ultra-rapid metabolizers.

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