• Fluvoxamine

    Fluvoxamine (Luvox, Luvox CR) has proven to be minimally effective and may be poorly tolerated in children and adolescents with ASDs, although it has been found to be efficacious in the management of repetitive behaviors, maladaptive behaviors, and aggression in some adults with autism.

    Doses for children range from 25 to 250 mg/day with some side effects. For adults, doses ranged from 50 to 300 mg/day and fluvoxamine was overall well-tolerated by adults.

    Side effects in children may include insomnia, aggression, increased rituals, anxiety, anorexia, increased appetite, irritability, decreased concentration, and increased impulsivity.

    Children with autism, aged 3 to 8 years, have shown only a 20% rate of response to this drug.

    Adults aged 18 to 53 years reveal a 53% response rate with reductions in repetitive thoughts and behavior, maladaptive behavior, and aggression.

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