Sertraline (Zoloft) is moderately effective and relatively well-tolerated in the management of repetitive behaviors and aggression in adults with ASDs. There is minimal data in children to draw definitive conclusions, although adverse effects in children may be greater with the use of sertraline.
Dosages in children range from 25 to 50 mg/day with worsening of behavior above 75 mg/day. Adults tolerated 25 to 200 mg/day.
Side effects are minimal, with the most common being weight gain and anxiety or agitation.